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In diet-induced obesity models, this inhibition has been observed to reduce white fat accumulation and promote lipolysis, effectively reprogramming metabolic pathways toward enhanced energy expenditure

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This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications

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In general, taking higher-than-recommended levels of vitamin B12 is well tolerated

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