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Cirrhosis may eventually lead to liver failure

Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes
European Journal of Experimental Biology , 3 , 203208

Initiate the dosing regimen for each patient individually, taking into account the patients underlying cause and severity of pain, prior analgesic treatment and response, and risk factors for addiction, abuse, and misuse [see Warnings]

This reduction may reflect changes in the expression of specific transcript variants arising from non-coding exons