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(iv) Augmented diacylglycerol (DAG) synthesis followed by PKC activation, which are linked to NOX activation, reduced insulin-stimulated NO production [100], upregulated expression of adhesion molecules, increased endothelin-1 (ET-1) release [101], and p66Shc activation [102,103]

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In WT plants, LET7 phosphatase activity is repressed by the inhibitory interaction between its PPase and TPR domains, supporting plant growth and survival