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Mithaiwala MN, Santana-Coelho D, Porter GA, Oconnor JC (2021) Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications

found that treatment with disulfiram (DSF) increased the production of cytoplasmic and mitochondrial ROS in MM cells, led to the loss of mitochondrial membrane potential and an increase in the level of lipid peroxidation, and caused a significant downregulation of ferroptosis - related genes including GPX4 ( T-5224 is an activator protein-1 (AP-1) inhibitor that specifically blocks the DNA-binding activity of the c-Fos/c-Jun heterodimer, thereby suppressing the expression of downstream pro-inflammatory cytokines such as TNF- and matrix metalloproteinases like MMP-3

Gonos, Proteasome activation delays aging in vitro and in vivo, Free Radical Biology & Medicine C, vol

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Looking forward, the integration of complementary technologies bulk, single-cell, spatial, and multi-omics together with computational modeling will be critical for connecting molecular-level discoveries in MuSC biology to systemic physiology and, eventually, to translational interventions for muscle aging
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