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This study was designed to systematically investigate the cartilage-protective effects of AOD9604, both alone and in combination with HA, using a well-established collagenase-induced OA rabbit model

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Its 536-patient trial found no significant weight loss vs placebo
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The clinical program and Phase 2b failure Phase 1 and 2a trials were successful , the peptide was safe, without significant side effects, and showed a mild lipolytic signal

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