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The latter is a potent but non-selective S1P receptor agonist, binding with similar affinity as S1P to S1P 1 , S1P 3 , S1P 4 and S1P 5 , but not S1P 2 [77]

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1 - 13 Illustratively, beneficial activity in heart assay includes counteraction of the doxorubicin cardiomyopathy, 41 distinctive arrhythmias induced by digitalis, 42 hyperkalemia, 43 hypokalemia, 44 succinylcholine, 45 bupivacaine, 46 and neuroleptics

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