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There are also studies investigating an effect of metal chelators and dietary approaches aimed at reducing intake of iron and copper [6]

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SIRT1 stimulates the deacetylation and functional enhancement of PGC-1-a pivotal controller of mitochondrial biosynthesis and cellular antioxidant capacity-while p53 concurrently modulates SLC7A11 expression, a core subunit of the cystine/glutamate antiporter essential for glutathione production (117)

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Originally isolated from human gastric juice by Dr

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