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This is especially true of opiate drugs, which inhibit gastric motility, delay gastric emptying, inhibit intestinal secretions, and slow bowel transit, thus predisposing users to nausea, constipation, and anorexia

de Jong SC, Stehouwer CD, van den Berg M, Kostense PJ, Alders D, Jakobs C, Pals G, and Rauwerda JA (1999b)

(PubMed) Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H

The GEN and NaS induced reduced DPOAE deficit hearing functions, impaired balance, and altered inner ear architecture might be mediated mostly through oxidative damage, apoptotic changes, and NF-B activation

Weissferdt A, Cascone T, Pataer A, Kalhor N, Moran C, Antonoff MB , Walsh GL, Bernatchez C, Gibons DL, Wistuba II, Roth JA, Zhang J, Roarty E, Landry LC, Vaporciyan AA, Heymach JV, Swisher S, Sepesi B

Due to the heterogeneity of this condition, a specific biomarker system for effective risk stratification has yet to be established (Bos and Ware, 2022