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(2018) ACS Chem Biol 13 : 2190-2202 PubMed: 29800515 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 6FMU, 6FMZ, 6FP4, 6FTC PubMed Abstract: Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases

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The Dependence on ROS for the Survival and Malignant Progression in TNBC Otto Warburg was the first to describe a propensity for cancer cells to metabolize glucose anaerobically even in the presence of oxygen (the Warburg effect), and suggested an explanation for this abnormal glucose metabolism in terms of impaired bioenergetic activity of the mitochondria [94]

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