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Description
As a result, patients on long-term opioid therapy often experience more pain, even at the same or higher doses of opioids, necessitating further increases in dosage that perpetuate the cycle of hyperalgesia
This was suggested to have occurred through the activation of 5 AMP-activated protein kinase (AMPK) and the reduction of total AMPK protein content in the gastrocnemius (GAST) muscle of ob/ob mice (189), thereby favoring an increase in carbohydrate oxidation, rather than an increase in fatty acid oxidation
Key determinants of GSH synthesis are the availability of the sulfur amino acid precursor, cysteine, and the activity of the rate-limiting enzyme, glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a modifier (GCLM) subunit
References Abdelrazik H
24 Age-changes in GH secretory dynamics at later stages of life are clinically measurable as frank alterations of the earlier patterns that can be quantified by measurement of pulse timing and amplitude
[DOI] [PMC free article] [PubMed] [Google Scholar] Naqvi S, Zhu C, Farre G, et al
