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Similar content being viewed by others Introduction Despite significant advancements in cancer research, the global cancer burden remains staggering, with one in five individuals developing cancer in their lifetime and one in nine men or one in twelve women dying from it 1

Targeting lactate transporters (MCT1/4 inhibitors) has been shown to restore T cell glycolysis and reinvigorate ICI responsiveness

[DOI] [PubMed] [Google Scholar] 5.Hill V.M., OConnor R.M., Sissoko G.B., Irobunda I.S., Leong S., Canman J.C., Stavropoulos N., Shirasu-Hiza M

.,Santiago-TiradoFH,PengT,YangM,HangHCDoeringTLA single protein S-acyl transferase acts through diverse substrates to determine cryptococcal morphology, stress tolerance, and pathogenic outcome.2015;11:e1004908 70

These results indicate that NFT induced the activation and translocation of Nrf2 into the nucleus