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Dopamine In principle, it is commonly acknowledged that altering neurotransmitter activity by drugs influences behavior while targeting the neurotransmitter of major systems affects the whole system
Dimet-Wiley A.L
Soft tissue injuries can be debilitating, causing pain and limitations in mobility

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Liu S, Tang Y, Shu H et al (2019) Dopamine receptor D2, but not D1, mediates descending dopaminergic pathwayproduced analgesic effect in a trigeminal neuropathic pain mouse model