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Rapidly evolving omics technologies continue to uncover novel HSC-specific targets for liver disease treatment (215)

The results demonstrated an objective response rate (ORR) of 55.2%, with a disease control rate (DCR) as high as 86.2%

While toll-like receptors (TLRs) signaling ensures protective immune response by recognizing invading pathogens and tissue-derived endogenous molecules, its overactivation perturbs the immune homeostasis by sustained release of pro-inflammatory mediators and subsequently underlies the development of many inflammatory diseases [296]

Instruments used in chemical synthesis NMR spectra were recorded using a JEOL JNM-ECZ400 spectrometer at 400 MHz for 1 H NMR and 100 MHz for 13 C NMR