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Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B

1 4ml Ampoule of Sterile Water

The ThT kinetic curve is characterized by a lag time ( t lag , the time in which ThT fluorescence reaches 5% of its maximum), dominated by the formation of oligomeric species not detectable by ThT, followed by an elongation phase, in which pre-fibrillar structures elongate to fiber, normally characterized by a time to half ( t 1/2 , the time in which the ThT fluorescence reaches half of its maximum value) and, finally, a plateau region in which the equilibrium is reached and the ThT fluorescence reaches its maximum value I max (Figure S1 in the Supporting Information)

Neurotoxic Triad Excitotoxicity, Oxidative Stress and Neuroinflammation Excitotoxicity occurs when abnormally high levels of glutamate are in the synaptic cleft between neurons, leading to prolonged activation of glutamate receptors, such as the NMDA receptor, resulting in increased calcium influx into the postsynaptic neuron and resultant cell death (Olney, 1990)

Bone 64 , 195203 (2014)

Both are peptide therapeutics rather than small molecules