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With daily dosing over an 8-week protocol, maintaining 10 or more rotation sites ensures adequate tissue recovery between injections

In some embodiments, PEG-PLGA-PEG block polymers are used to control the release rate of the active agents with different physical properties
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Studies show the depth and percentage of microneedle penetration correlate with application forces, which influence the extent of enhancement in skin permeability of GHK-Cu

DOI:10.1128/IAI.73.5.2873-2880.2005 13
