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These results highlight hepsin's crucial role in controlling APAP-induced liver toxicity by regulating the cellular abundance of GJ proteins, which can affect the transmission of toxic metabolites or cell death signals and potentially increase oxidative stress

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The promotion of mTOR effector protein kinase ribosomal S6 protein kinase 1 (S6K1) serves as an important regulator of translation, with mTOR stimulating translation through phosphorylation of S6K1/2