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Unexpectedly, subjects receiving CNTF in clinical trials for this indication experienced weight losses of 10--15%, prompting researchers to consider using CNTF to treat obesity [71]

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It was proposed that chelating agents like EDTA, N -hydroxyethylethylenediamine- NN'N' -triacetic acid (Walsh et al., 2003) and to a lesser extent nitrilotriacetic acid (Haque and Russell, 1974) serve as a potentiating agent, as they destabilize the outer membrane and create easier access for other compounds