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A possible explanation for unexpected or contrasting observations is that forcing the plant to overproduce PCs caused a severe GSH depletion, which disables GSH in fulfilling its other important functions in antioxidative defense and signaling

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The complex pathophysiology of silicosis with the activation of multiple pro-inflammatory, pro-oxidant, and pro-fibrotic pathways indicates that besides the currently used anti-fibrotics pirfenidone and nintedanib, other approaches (anticytokines, antioxidants including NAC, and agents influencing the autophagic-lysosome system or increasing cAMP) may also be of benefit [67,185]

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Abnormal gut microbiota, like in those with severe acute malnutrition (SAM), could also lead to decreased thiamine absorption [23]

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