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Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition

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Vitamin B12 levels can rise temporarily after supplements or injections

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Category 2 is the FDA's designation for bulk drug substances nominated for compounding consideration that have been identified as presenting potential safety risks and are currently ineligible for routine compounding under Section 503A