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This multimodal death network underpins the adaptability and therapeutic resistance of PD neurodegeneration, necessitating combinatorial targeting for effective intervention

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Another feature of the recovery process is the removal of damaged mitochondria by a form of autophagy termed mitophagy84,85, and inhibition of mitophagy by lysosomal cholesterol accumulation was shown to sensitize mice to APAP hepatotoxicity86

Therefore, according to the CPIC guidelines, it is strongly recommended not to use any CYP2D6 strong or moderate inhibitors when prescribing tamoxifen among CYP2D6 NMs and UMs[15]

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