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meanwhile, it regulates the expression of key glycolytic enzymes (e.g., HK2) to drive metabolic reprogramming ( 4.2 Emphysema Emphysema represents another critical pathological hallmark of COPD, defined as abnormal permanent enlargement of the airspaces distal to the terminal bronchioles, accompanied by destruction of alveolar walls and without significant fibrosis. Clinically, two primary subtypes predominate: centrilobular emphysema and panlobular emphysema

B.SouthwickS

Romero-Haro AA, Figuerola J, Alonso-Alvarez C

Mart-Centelles, R

Activated microglia produced inflammatory mediators, such as prostaglandin E 2 , interleukin-1 TNF, ROS (peroxideH 2 O 2 , superoxideO 2 ), and reactive species nitrogenous (RNS: NO

In our study, the top 3 hub proteins for the CBZ targets based on the degree were identified, namely Epidermal growth factor receptor (EGFR), Glycogen synthase kinase 3 beta (GSK3B) and Signal Transducer and Activator of Transcription 3 (STAT3), whereas EGFR, GSK3B, and Glutamate metabotropic receptor 5 (GRM5) were the ones identified based on BC score