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Recently, DmToll-9 was reported to interact with dsRNA in endosomes and to induce the expression of the siRNA pathway genes Dcr-2 and Ago-2 , which results in protection against DCV ( Dicistroviridae ) infection (254)

2022 Jul 2

Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor eradication

Safety 147, 954962

From a mechanistic perspective, these outcomes are mediated by multi-system endocrine adaptations, including suppression of the HPG axis, alterations in insulin and glucose-regulating hormones, reduced triiodothyronine (T3), elevated cortisol, and disruptions in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling [92]

Consequently, these models are best suited for investigating acute innate immune responses or tumorimmune interactions, whereas adaptive immune mechanisms are more appropriately studied in immunocompetent adult zebrafish or humanized mouse models