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At the molecular level, it is reinforced by the induction and upregulation of TYR, which acts as the pivotal enzyme in the rate-limiting step of melanin production [46]

BIOTIN C TC DNG G

Synergistic Lewis acid-base sites of ultrathin porous Co 3 O 4 nanosheets with enhanced peroxidase-like activity

10.1165/rcmb.2017-0289OC 54 HuB.Gharaee-KermaniM.WuZ.PhanS

J Invest Dermatol 134:15121518

To avoid the non-linear constraint imposed in equation (4) two variables, y + and y , are introduced to convert the problem to its equivalent linear form