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rebaudiana in various diseases, systematic clinical evidence regarding its optimal and safe dosage for different indications remains limited ( In addition, future studies should focus on multi-omics integration, elucidation of synergistic mechanisms among key constituents, and pharmacokinetic profiling, particularly through advanced technologies such as UPLC-DAD-QTOF-MS, bioassay-guided screening, and computer-aided drug design (Yi et al., 2010