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doi: 10.1038/laban0908-421

[DOI] [PubMed] [Google Scholar] 114.Boukhzar L., Hamieh A., Cartier D., Tanguy Y., Alsharif I., Castex M., Arabo A., Hajji S.E., Bonnet J.J., Errami M., et al

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Alpha-lipoic acid (a-LA) was also proven to improve cognitive impairment, slow cognitive decline (Fava et al., 2013), block iron overload, lipid peroxidation, and inflammatory responses in AD patients (Zhang et al., 2018)

The latter is superior to the oral route since glutathione passes directly into systemic circulation resulting in a much higher rate of absorption compared to that achieved by oral intake

It is important to note that the physico-chemical properties (e.g., complex formation, nucleophilic reactivity, redox properties) and biological functions of glutathione could be significantly different at different protonation states (i.e., in solutions with different pH values) [90,91,92,93] and its redox behavior [94,95]