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Human studies show that OPN3 is expressed in immune cells, lungs, smooth muscle, skin, blood vessels, brain, and eyes.[ref] OPN3 has recently been shown to be involved in the relaxation of the lung smooth muscle in the presence of blue light (~450 nm).[ref] Genetic variants in OPN3 have been associated with asthma susceptibility in multiple studies, tying into the relaxation of the airway muscles.[ref] OPN5 encodes neuropsin , which is sensitive to visible violet light wavelengths (~380 nm)

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