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In contrast, m705RP cells had dramatically increased phosphorylation levels of proteins participating in RNA processing and splicing, RNP synthesis, ribosome biogenesis, and chromatin assembly and remodeling, in comparison with m705 cells (Supplemental Figure 3E)

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The induction occurred when Nrf1 or Nrf2 was silenced using siRNA but whether CREB binds to the ARE4 alone or requires the participation of other transcription factors is unknown