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Description
For patients who have not achieved adequate glycemic control with existing medications or lifestyle modifications alone, GLP-1 therapy offers a potent alternative with greater potency and longer half-life compared to some other GLP-1 RA therapies
The MHRA advises following current clinical guidelines, and it signposts to the NICE Clinical Knowledge Summary (CKS) on this topic (NICE, 2022)

The freeze-dried form eliminates water, which is the primary catalyst for degradation reactions

This combination has been investigated in preclinical models examining synergistic effects on tissue recovery and inflammatory signaling pathways

But until then, the evidence ceiling is 12 weeks in humans and 90 days in rodents

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