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No adverse effects were reported, but rigorous, large-scale trials are lacking, according to NIH

Targeting TGF-beta in prostate cancer: therapeutic possibilities during tumor progression

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Though allergies to cobalt are rarely dangerous, taking any form of B12 supplement, whether by injection, tablet, or topically applied gel, may result in an uncomfortable, itchy rash

If you already know you need a B12 shot, the visit can be straightforward

Sources: Harvard Health, Cleveland Clinic Sources: Harvard Health, Cleveland Clinic Like most vitamins, B12 cannot be made by the body and must be received through food or supplementation Up to 15% of Americans are deficient in B12, but most don't know they are deficient Likelihood of B12 deficiency increases with common factors like nutrient deficiencies or gut-related health issues Subcutaneous injections deliver B12 directly into the tissue for more efficient absorption than other methods (like pills) Slowing aging has never been simpler Explore our treatments Browse our offerings or tell us about your health goals