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Nevertheless, synergistic coupling of the increase in CDO concentration that can be achieved by regulation of ubiquitination/degradation of CDO with the increase in catalytic efficiency that can be achieved by Cys-Tyr cofactor formation, plus the increased catalytic life time of the mature enzyme that results from Cys-Tyr cofactor formation, provides the cell with the capacity for a many-fold increase in CDO activity in response to a high intake of protein or sulfur amino acids