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Sublingual B12, which bypasses the gastrointestinal tract, is the least invasive and potentially most cost-effective option, especially for individuals with impaired absorption, making it an attractive alternative for long-term and patient-friendly management (Houle et al., 2014

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In a zebrafish model, Grx2c was found to be important for the development of the axonal scaffold, as silencing of Grx2c ultimately prevented the neuron differentiation and promoted neuron cell death in nearly 97% of embryos [33]

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