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The distinguishing feature of this class of compounds is the highly reactive electrophilic N=C=S structural moiety, which undergoes several reactions in biological systems

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Results have also revealed that chondrocytes from Hfe-KO mice were more likely to develop OA-related phenotypic characteristics, such as upregulation of MMPs expression, decreased production of extracellular matrix, and decreased expression of aggrecan

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In addition, allergic reactions such as itching and reddening of the skin have been observed in connection with the intake of glutathione
