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Mitochondrial diseases

Vitamin B12 and One-Carbon Metabolism Vitamin B12 (cobalamin) is an essential cofactor for several enzymes involved in one-carbon metabolism and energy-related pathways: Methionine Synthase: B12-dependent remethylation of homocysteine to methionine is central to the generation of S-adenosylmethionine (SAM), a universal methyl donor used in DNA, protein, and phospholipid methylation

In general, the core precursors of phospholipid and TAG synthesis are PA and DAG

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Therefore, the proliferation and migration ability of endothelial cells is very important for angiogenesis