glutathione s tansferase Frontiers Glutathione transferases: substrates, inihibitors and
Description
Within the nucleus, Nrf2 heterodimerizes with small Maf proteins and binds to cis-regulatory DNA sequences termed Antioxidant Response Elements (AREs)
J Immunol Res 2014:565320
Curr Opin Pharmacol (2017) 35:309
Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans
38 ObeidR.FedosovS
Under pathological conditions, NOX is the main cause of the ROS increase, thus leading to a decrease in BH4
