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It is theorized that this process could involve the activation of the PI3K-Akt and JAK2-STAT5 pathways (pathways with essential roles in cell growth, survival, and metabolism), along with a reduction in NF-B-mediated gene transcription (proinflammatory pathways that can lead to cell damage and death)

Biochim Biophys Acta 1269: 153161, 1995 [DOI] [PubMed] [Google Scholar] 44

Deregulation of Ran in cancer has been reported in several tissue types [17]

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