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To study the effect of BCAT2 inhibition in a whole-body system, we generated a murine disease model of MMA by monoallelic CRISPR targeting to mitigate potential homozygous lethality (see Methods for more details)

[DOI] [PubMed] [Google Scholar] 54.Posar A, Visconti P

Cognitive fatigability is easily and quickly assessed through TAP (Test for Attention) alertness examinations

doi: 10.1016/j.neuron.2017.09.003 Summary Keywords apolipoproteins, fatty acid metabolism, lipid oxidation, vascular biology, Alzheimers disease Citation Huguenard CJC, Cseresznye A, Darcey T, Nkiliza A, Evans JE, Hazen SL, Mullan M, Crawford F and Abdullah L (2023) Age and APOE affect L-carnitine system metabolites in the brain in the APOE-TR model

How to structure a sensible 12 week trial Because most measurable effects appear after about twelve weeks, design your trial with that timeframe in mind