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Because IB normally binds to NF-B, the latter's nuclear localization sequence (NLS) is masked, resulting in its main location in the cytoplasm, while removal of IB exposes the masked site to induce the nuclear translocation of NF-B, making it bind to the promoter regions of its downstream genes [34], such as cyclooxygenase-2 (COX-2), IL-6, and inducible nitric oxide synthase (iNOS)

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