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Int J Biochem Cell Biol 37: 822834

doi: 10.1038/nature04250

Oxidative stress is a major hallmark of skin aging that may lead to DNA damage, mitochondrial dysfunction, and inflammation at the cellular levelall of which contribute to aging skin

For example, miR-21 modulates glycolysis in CD4 + T cells through the PTEN/PI3K/AKT pathway, accelerates the cell cycle, promotes CD4 + T cell polarization toward Th2, and induces fibrogenic cytokine IL-13 expression, which participates in arsenite-mediated fibrosis of the liver [110]

Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

All of these findings provide a reference for the pharmacological study of newly discovered plant-derived antitumor drugs