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Neurological concerns : Brain fog or difficulty concentrating

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Mitochondria, versatile organelles involved in cellular energy production, apoptosis regulation, and the orchestration of various biosynthetic pathways, have emerged as key players in the function and viability of leukocytes, central to cytokine production and regulation (Picca et al., 2021

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For instance, a recent clinical trial on SRT as an adjunct regimen for asymptomatic cryptococcal antigenemia reported serious adverse events (psychosis, aggressive behavioral changes, and serotonin syndrome) [71]

To test the possible increase in potency of the two drugs when given simultaneously, we injected a total volume of 4 ml of combined doses of L838,417 and CLP257 in a fixed dose ratio of \([{\mathrm{L 838,417]/[{\mathrm{CLP 257]\) = 1:55, given the relative EC50s of the two drugs calculated from the respective dose response curves with a priori assumption on the collapse at high doses of L838,417 (Fig