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Nature 288, 715717 (1980)

Without adequate protection, pepsin would cleave the bonds between its amino acids, rendering it inert

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Advise males with female partners of reproductive potential to use effective contraception during treatment with Pemetrexed Injection and for 3 months after the last dose [see Warnings and Precautions (5.7) and Use in Specific Populations (8.3)]

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