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Given the possibility that cimetidine may benefit a subset of patients without significant AEs in the context of a small total sample exposed to the drug (n=40, including the RCT), the lack of long-term follow-up data on sufficient numbers of patients, and its potential to interact with other drugs, oral cimetidine was designated as an Option

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Light and heat can degrade the vitamin over time, reducing its potency

however, the procedure is unable to restore the intervertebral space height or maintain the stability of the intervertebral space

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Technical differentiation appears in specialized formulations