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Remarkably, overexpression of HSL alone, in the absence of the M2-polarizing cytokine (IL-4), was sufficient to induce a pro-resolving phenotype in nave macrophages
It's a dynamic state influenced by its environment
Butyrate appears also involved in reducing the immune response to LPS, helping T-cell differentiations, and decrease IL-6 and IL-12 secretion
Eligibility and exclusion criteria Studies selected were original articles publishing results on the effect of different peptides on osteoblasts and osteoprogenitor cells as well as in vivo studies on bone healing
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