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DNA damage can cause aging by affecting transcription, apoptosis signaling or cellular senescence or through somatic mutations and telomere shortening [44,45,46]

Heat is the biggest risk

Researchers must follow strict safety protocols, including protective equipment and proper waste disposal

Antioxidants and allergic disease: a case of too little or too much

Abbreviations CVD: Cardiovascular disease CHD: Congenital heart disease AAA: Abdominal aortic aneurysm TAD: Thoracic aortic dissection CAD: Coronary artery disease Hcy: Homocysteine HHcy: Hyperhomocysteinemia CBS: Cystathionine -synthase MTHFR: 5,10-Methylenetetrahydrofolate reductase ECs: Endothelial cells VSMCs: Vascular smooth muscle cells HUVECs: Human umbilical vein endothelial cells HASMCs: Human aortic smooth muscle cells ECM: Extracellular matrix MMPs: Matrix metalloproteinases PDGF: Platelet-derived growth factors References Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER (2019) Homocysteine and hyperhomocysteinaemia

It can be safely used alongside other ingredients like niacinamide, hyaluronic acid, retinoids and Vitamin C