nicotinamide riboside interactions with glutathione Frontiers Frontiers | The mechanisms crosstalk

Vitamin B12 supplements are generally considered safe when taken in appropriate dosages

This reduction in systemic inflammation is likely attributable to the high intake of antioxidant-rich foods, such as fruits, vegetables, and whole grains, which counteract oxidative stress and mitigate the effects of aging on the brain

The evidence base is largely preclinical (cell and animal), with very limited human data

10.1016/j.chmed.2021.09.001 220 ZhaoR.LiuW.WangM.ZhangY.PanL.FengF.et al (2020)

This might indicate that the fasting-induced differential stress response between tumor and normal tissue may also be achieved in humans

doi: 10.4049/jimmunol.1501603