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There were karyopyknosis and degeneration of Purkinje cells of the cerebellar cortex and pyramidal cells of the hippocampus (Figure 13 and Figure 14)

We dont yet know how they might affect: Egg quality or endometrial health Embryo implantation Pregnancy outcomes, especially in early gestation Until more evidence becomes available, the safest approach is to treat these medications as incompatible with active fertility treatment or pregnancy

This effect has major implications for treating extrapyramidal symptoms and tardive dyskinesia from antipsychotic medications

ORATORIO-HAND included patients who are older (65 and under) and with more disability (EDSS 8.0 and below) than in the pivotal trial

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade
