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As an extracellular copper-dependent monoamine oxidase, Lysyl oxidase (LOX) catalyzes the crosslinking of collagen and elastin proteins into insoluble mature fibers to contribute tensile strength of collagen fiber and elasticity of elastin fiber 15,16,34,36,37,38

101 Thus, EMTs induced by TGF- are associated with multiple programs and outcomes in different contexts: mesendodermal differentiation in epiblast progenitors and fibrogenesis in adult epithelial cells and carcinoma cells

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