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Criteria for discontinuing or modifying allocated interventions The participants can be withdrawn from the trial at any time with no effect on their ongoing care in case of any major ailment necessitating the institution of new modalities of treatment or in case of non-compliance of the treatment regimen (minimum 80% compliance is essential to continue in the study) or when the blood pressure is not under control

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Based on these pricing models and related market inputs and assumptions referred to in this section below, WFS determined an estimated value for the securities by estimating the value of the combination of hypothetical financial instruments that would replicate the payout on the securities, which combination consists of a non-interest bearing, fixed-income bond (the debt component ) and one or more derivative instruments underlying the economic terms of the securities (the derivative component )

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