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International Journal of Molecular Sciences (2018) 10

[emphasis added] Poor vagal tone and abnormal vagal activity is present is present in dysautonomia, a cluster of conditions can be caused by system bioenergetic deficits that are not localized to the gut

In essence, phytosterols and alkaloids can interfere with tumor cell survival on multiple frontsfrom membrane signaling and cell cycle regulation to intrinsic apoptosisoften targeting master regulators like NF-B, Akt/mTOR, or microtubules