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The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2

Similar lesions have occasionally been described in patients, including one with systemic lupus erythematosus, following the use of sunbeds for artificial tanning
