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Company founder Brigham Buhler is a former pharmaceutical sales rep

In a small-animal model of arthritis, zonulin acted as a disruptor of the tight junction barrier by reducing expression of occludin and ZO-1, associated with increased intestinal permeability to macromolecules (48)

Mice expressing dominant-negative N-cadherin develop phenotype similar to IBD This study possibly provided the first experimental in vivo evidence that manipulating mucosal epithelial cell-to-cell adhesion can modulate mucosal barrier properties and that it promotes inflammation

Front Mol Neurosci

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Oxidative Stress Vitamin B12 also enhances the function of reproductive organs